Food Timeline- -beverages. Food. Timeline library. Food Timeline FAQs: beverages... Food historians tell us progenitors of these items likely happened by . Both are predicated on stable, stationary civilizations. The Archaeological evidence confirms wine and beer were regularly consumed by the Neolithic period. While none of our historians state outright one predates the other, brewing may present some older evidence. As certain types of sweet fruit, and also honey, will ferment on. Certainly the fermented drinks of the Old and New Worlds represent independent discoveries, and it could well be that the development of rice.
Asia was quite unconnected with that of the varied cereal and wine concoctions in the European area.. The Acid- Alkaline Myth: Part 2. Here we go again with the personal attacks. So they try to attack the messenger instead in a poor attempt to make the messenger to appear as ignorant as they are. For example, who said there is no cure for cancer yet? Although O(3) has dangerous effects, yet researchers believe it has many therapeutic effects. Ozone therapy has been utilized and heavily studied for more than a century. Its effects are proven, consistent, safe and with minimal and preventable side effects. Medical O(3) is used to disinfect and treat disease. Mechanism of actions is by inactivation of bacteria, viruses, fungi, yeast and protozoa, stimulation of oxygen metabolism, activation of the immune system. Medication forms in a gaseous state are somewhat unusual, and it is for this reason that special application techniques have had to be developed for the safe use of O(3). In local applications as in the treatment of external wounds, its application in the form of a transcutaneous O(3) gas bath has established itself as being the most practical and useful method, for example at low (sub- atmospheric) pressure in a closed system guaranteeing no escape of O(3) into the surrounding air. Ozonized water, whose use is particularly known in dental medicine, is optimally applied as a spray or compress. Diseases treated are infected wounds, circulatory disorders, geriatric conditions, macular degeneration, viral diseases, rheumatism/arthritis, cancer, SARS and AIDS. Free PMC Article. Int J Cancer. 2. 00. May 1. 5; 1. 22(1. Since the biomolecule ozone was found to inhibit growth of various carcinoma cells in vitro we here applied the highly aggressive and lethal VX2 carcinoma HNSCC tumor model of the New Zealand White rabbit to test whether ozone exerts antitumorous effects in vivo. Therapeutic insufflation of medical ozone/oxygen (O(3)/O(2)) gas mixture into the peritoneum (O(3)/O(2)- pneumoperitoneum) at an advanced stage of tumor disease led to a survival rate of 7/1. Six of the seven surviving rabbits presented full tumor regression and the absence of local or distant lung metastases. Insufflation of pure oxygen (O(2)) resulted in a survival rate of 3/1. Of the 1. 4 sham- treated animals only 1 had spontaneous tumor remission and survived. No adverse effects or changes in standard blood parameters were observed after repeated intraperitoneal insufflations of the O(3)/O(2) or O(2) gas. Animals with O(3)/O(2)- induced tumor eradication developed tolerance against reimplantation of the VX2 tumor. This could be reversed by immune suppression with a combination of dexamethasone and cyclosporin A suggesting an antitumorous effect of O(3)/O(2)- mediated activation of the body’s own immunosurveillance. Although the exact mechanisms of action are still unclear the present data point to O(3)/O(2)- pneumoperitoneum as a promising new strategy in anticancer therapy. Evidence- Based Complementary and Alternative Medicine. Volume 1 (2. 00. 4), Issue 3, Pages 3. Original Article. Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study. Bernardino Clavo,1,7 Ana Ruiz,1,7 Marta Lloret,1,7 Laura L. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract. Advanced head and neck (H& N) tumors have a poor prognosis, and this is worsened by the occurrence of hypoxia and ischemia in the tumors. Ozonetherapy has proved useful in the treatment of ischemic syndromes, and several studies have described a potential increase of oxygenation in tissues and tumors. The aim of this prospective study was to evaluate the clinical effect of ozonetherapy in patients with advanced H& N cancer in the course of their scheduled radiotherapy. Over a period of 3 years, 1. H& N tumors who were undergoing treatment in our department with non- standard fractionated radiotherapy plus oral tegafur. A group of 1. 2 patients was additionally treated with intravenous chemotherapy before and/or during radiotherapy. In the other group of seven patients, systemic ozonetherapy was administered twice weekly during radiotherapy. The ozonetherapy group was older (6. P = 0. 0. 06), with a higher percentage of lymph node involvement (7. P = 0. 0. 19) and with a trend to more unfavorable tumor stage (5. IVb + IVc stages, P = 0. However, there was no significant difference in overall survival between the chemotherapy (median 6 months) and ozonetherapy (8 months) groups. Although these results have to be viewed with caution because of the limited number of patients, they suggest that ozonetherapy could have had some positive effect during the treatment of our patients with advanced H& N tumors. What is a low carb diet, really? When can a low carb diet be beneficial? Should everyone follow a low carb diet? Or, can a low carb diet ruin your health? Food Timeline--history notes: beverages. Beef tea What is beef tea? A concentrated protein beverage extracted from the essence of beef used to restore human health. The adjuvant administration of ozonetherapy during the chemo–radiotherapy for these tumors merits further research. Full article and citing articles available- http: //www. Evidence- Based Complementary and Alternative Medicine. Volume 1 (2. 00. 4), Issue 1, Pages 9. Original Article. Ozone Therapy for Tumor Oxygenation: a Pilot Study. Bernardino Clavo,1,5 Juan L. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract. Tumor hypoxia is an adverse factor for chemotherapy and radiotherapy. Ozone therapy is a non- conventional form of medicine that has been used successfully in the treatment of ischemic disorders. This prospective study was designed to assess the effect of ozone therapy on tumor oxygenation. Eighteen subjects were recruited for the study. Systemic ozone therapy was administered by autohemotransfusion on three alternate days over one week. Tumor oxygenation levels were measured using polarographic needle probes before and after the first and the third ozone therapy session. Overall, no statistically significant change was observed in the tumor oxygenation in the 1. However, a significant decrease was observed in hypoxic values . When individually assessed, a significant and inverse non- linear correlation was observed between increase in oxygenation and the initial tumor p. O2 values at each measuring time- point, thus indicating that the more poorly- oxygenated tumors benefited most (rho = . Additionally, the effect of ozone therapy was found to be lower in patients with higher hemoglobin concentrations (rho = . Despite being administered over a very short period, ozone therapy improved oxygenation in the most hypoxic tumors. Ozone therapy as adjuvant in chemo- radiotherapy warrants further research. Full article and citing articles available- http: //www. Mediators Inflamm. Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin- 8 production. Bocci V 1, Valacchi G, Corradeschi F, Fanetti G. Author information. Abstract. Ozone (O3) is a controversial gas because, owing to its potent oxidant properties, it exerts damaging effects on the respiratory tract and yet it has been used for four decades as a therapy. While the disinfectant activity of O3 is understandable, it is less clear how other biological effects can be elicited in human blood with practically no toxicity. On the other hand plasma and cells are endowed with a powerful antioxidant system so that a fairly wide range of O3 concentrations between 4. M) are effective but not deleterious. After blood ozonation total antioxidant status (TAS) and plasma protein thiol groups (PTG) decrease by 2. TBARS) increases up to five- fold. The increase of haemolysis is negligible suggesting that the erythrocyte membrane is spared at the expense of other sacrificial substrates. While there is a clear relationship between the ozone dose and IL- 8 levels, we have noticed that high TAS and PTG values inhibit the cytokine production. This is in line with the current idea that hydrogen peroxide, as a byproduct of O3 decomposition, acts as a messenger for the cytokine induction. Free PMC Article. J Biol Regul Homeost Agents. Jul- Sep; 1. 2(3): 6. Studies on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone. Bocci V1, Valacchi G, Corradeschi F, Aldinucci C, Silvestri S, Paccagnini E, Gerli R. Author information. Abstract. The acceptance of any complementary medical approach is conditioned by the results obtained after the same scientific scrutiny applied in orthodox medicine. Otherwise any claim of efficacy remains in the realm of fiction. In the case of ozone therapy, the mechanisms of action have remained nebulous and in a series of publications we are trying to present the biochemical, immunological and morphological evidence in favour or against ozone therapy. We have now shown that ozone (O3) dissolved in the water of either plasma or serum or physiological saline generates reactive oxygen species (ROS), of which hydrogen peroxide (H2. O2) can be unequivocally demonstrated by using specific methods for its detection. Lipids present in plasma preferentially those present in lipoproteins, undergo peroxidation that is somewhat O3- dose dependent and can be observed by the measurement of thiobarbituric acid reactive substances (TBARS). While the generation of H2. O2 is crucial in activating both biochemical (hexose monophosphate shunt) and immunological (via the transcription factor NF- k. B) mechanisms, the role of lipid oxidation products (LOP) remains to be investigated. We have shown here that there is a small but consistent induction of some cytokines (TNF- alpha, IFN- gamma and IL- 2) when human blood is directly exposed to O3 concentrations up to 1. On the other hand, isolated blood mononuclear cells (PBMC) in tissue culture medium are far more sensitive to the oxidant action of O3 as shown by a progressive reduction of the proliferation index with comparatively far lower O3, concentrations.
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